Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2.
نویسندگان
چکیده
The receptor for IL-26 (AK155), a cytokine of the IL-10 family, has not previously been defined. We demonstrate that the active receptor complex for IL-26 is a heterodimer composed of two receptor proteins: IL-20R1 and IL-10R2. Signaling through the IL-26R results in activation of STAT1 and STAT3 which can be blocked by neutralizing Abs against IL-20R1 or IL-10R2. IL-10R2 is broadly expressed on a wide variety of tissues, whereas only a limited number of tissues express IL-20R1. Therefore, the ability to respond to IL-26 is restricted by the expression of IL-20R1. IL-10, IL-19, IL-20, IL-22, and IL-24 fail to signal through the combination of IL-10R2 and IL-20R1 proteins, demonstrating that this receptor combination is unique and specific for IL-26.
منابع مشابه
of April 14 , 2017 . This information is current as Receptor 1 and IL - 10 Receptor 2 Receptor Complex Composed of IL - 20 Cutting Edge : IL - 26 Signals through a Novel Kotenko
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ورودعنوان ژورنال:
- Journal of immunology
دوره 172 4 شماره
صفحات -
تاریخ انتشار 2004